Opus™ BA is a synthetic bioactive solution that is easily hydrated and flexible. A carefully selected trifecta of components creates an ideal environment for bone growth building on the earlier generations of synthetic bone grafts.
Carbonate Apatite Bone Mineral 50%
Higher osteoclastic and osteoblastic activity than β-TCP & HA1
Resorption & remodeling similar to human bone2,3
45S5 Bioactive Glass 30%
Ideal particle range and size (100-300μm)4,5,6
Ability to stimulate the growth and osteogenic differentiation of osteoblasts7
Type 1 Collagen 20%
Binds proteins and cells and retains biological factors9
Opus BA combined with either autogenous bone marrow or autograft with saline is indicated for bony voids or gaps, that are not intrinsic to the stability of the bony structure; Opus BA can also be used with autograft as a bone graft extender. The device is to be gently packed into bony voids or gaps of the skeletal system (i.e., posterolateral spine). These defects may be surgically created osseous defects or osseous defects created from traumatic injury to the bone. The device resorbs and is replaced with bone during the healing process.
Kanayama, K., Sriarj, W., Shimokawa, H., Ohya, K., Doi, Y., Shibutani, T. 2011. Osteoclast and Osteblast Activities on Carbonate Apatite Plates in Cell Cultures. J. Biomaterials, 26, 435-436.
Matsuura, A., Kubo, T., Doi K., Hayashi, K., Morita, K., Yokota, R., Hayashi, H., Hirata, I., Okazaki, M., Akagawa, Y. (2009). Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents. Dental Materials Journal, 28(2), 234-242.
Ellies, LG., Carter, J.M., Natiella, J.R., Featherstone, J.D.B., Nelson, D.G.A. (1988). Quantitative analysis of early in vivo tissue response to synthetic apatite implants. J. of Biomed. Mater. Res., 22, 137-148.
Oonishi, H., Kushitani, S., Yasukawa, E., Iwaki, H., Hench, L.L., Wilson, J., Tsuji, E., Sugihara, T. (1997). Particulate Bioglass Compared With Hydroxyapatite as a Bone Graft Substitute. Clinical OrthoPaedics and Related Research, 334, 316-325, Lippincott-Raven Publishers, Philadelphia, PA.
Schepers, E.J.G., Ducheyne, P. (1997). Bioactive glass particles of narrow size range for the treatment of oral bone defects: a 1-24 month experiment with several materials and particle sizes and size ranges. Journal of Oral Rehabilitation, 24, 171-181.
Lindfors, N. C., Koski, I., Heikkilä, J. T., Mattila, K. and Aho, A. J. (2010), A prospective randomized 14‐year follow‐up study of bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors. J. Biomed. Mater. Res., 94B, 157-164. doi:10.1002/jbm.b.31636
Xynos, I.D., Hukkanen, M.V., Batten, J.J., Buttery, L.D.K, Hench, L.L., Polak, J.M. (2000). Bioglass 45S5 stimulates osteoblast turnover and enhances bone formation In vitro: Implications and applications for bone tissue engineering. Calcif Tissue Int. 67(4), 321-9.
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